mgh logos Radiology Rounds
A Newsletter for Referring Physicians
Massachusetts General Hospital
Department of Radiology
Partners and Harvard logos

 
Volume 6 Issue 3 - March 2007
Download PDF Version of this Article
Bookmark this Site
  Archived Issues of Radiology Rounds
MGH Department of Radiology Website
 
Incidentally Detected Adnexal Masses
 
  • Incidental adnexal masses are common in both pre- and postmenopausal women; the vast
    majority are benign

  • Ultrasound demonstrates high sensitivity but low specificity for detecting ovarian cancer. MRI
    evaluation of adnexal masses indeterminate on ultrasound increases specificity, decreasing
    resection of benign lesions

  • An algorithm to evaluate adnexal masses with imaging is presented.  The goal is to identify patients
    with definitely benign lesions from those that require further clinical evaluation for ovarian cancer



Natural History of Adnexal Masses
Incidental Adnexal Lesion Seen in Imaging
Ultrasound Characterization of Adnexal Masses
MRI Characterization of Adnexal Masses
Scheduling
Further Information
References

O
varian cancer is the leading cause of death from gynecological cancers, with 22,480 estimated new cases and 15,280 deaths in 2007. If it is diagnosed at Stage I, there is an almost 90% survival rate at 5 years; but if diagnosed at an advanced stage, as are most cases, the 5 year survival rate is <30%.  Several screening programs, undertaken with the hope of detecting ovarian cancer at an early stage, have provided valuable insight into the incidence of adnexal masses, their natural history, and strategies for their management.

Natural History of Adnexal Masses
Screening trials using imaging have proven unsuccessful because benign adnexal lesions are relatively common whereas ovarian cancer is rare.  In one study following >15,000 asymptomatic postmenopausal women over an average period of 6.3 years, 18% developed unilocular cysts of which 69% resolved spontaneously. In the 10 women diagnosed with ovarian cancer, the cysts either developed complex features, resolved before diagnosis, or the cancer developed in the contralateral ovary. The risk of cancer eventually developing from a unilocular cyst was calculated to be <0.1%. Complex ovarian cysts show a reported incidence of 3.2% in postmenopausal women 55% of which resolve within 60 days.

Screening trials have also revealed that the majority of ovarian cancers demonstrate very rapid growth.  In one study, the frequency of ovarian cancer in women with persistent complex cysts was 6.1% and all but one grew during the 4-6 week period between initial detection and follow-up scanning.  In another, in which women were examined every 6 months with transvaginal ultrasound, all 10 of the ovarian cancers detected were at advanced stage (III or IV), having developed within the 6 month interval between screenings. From this, the authors estimated a tumor volume doubling time for ovarian cancer of <3 months and concluded that periodic imaging is ineffective in early detection.

Incidental Adnexal Lesion Seen in Imaging
An algorithm for the use of imaging for the evaluation of incidentally detected adnexal masses is shown in Figure 1.  An adnexal lesion found incidentally, usually on CT or ultrasound examination, does not need further imaging characterization if it is obviously malignant, e.g. concurrent omental implants, other evidence of peritoneal disseminated disease, or lymphadenopathy. In addition, simple cysts less than 5-6 cm, with no solid components in a premenopausal woman, are likely benign and do not require further imaging. (Simple cysts that are larger may warrant additional imaging to document resolution as these cysts can torse and may need to be removed surgically if they persist).  On the other hand, lesions found in postmenopausal women and those that have solid components require further evaluation.
 
Table 1. Incidence of Ovarian Cysts
Ovarian cyst
Estimated Prevalence
Risk of Malignancy
Unilocular Ovarian Cyst

Postmenopausal,
<10 cm:  3-18%

Postmenopausal,
>2.5 cm: 6.4%

Premenopausal,
>2.5 cm: 12.6%

0 - 0.1%
Complex Ovarian Cyst
Postmenopausal, 3.2%
3%

For this purpose, follow-up imaging (usually within 6 weeks) is recommended either with ultrasound or MRI.  Adnexal lesions can be definitively characterized as benign if they demonstrate specific imaging features or if they resolve on follow-up imaging.  If not definitely benign on follow-up, the patient should be evaluated clinically to exclude the possibility of ovarian cancer.

Clinical evaluation for ovarian cancer includes medical and family history, physical exam and serum CA-125 levels which, in combination with imaging findings, determine the index of suspicion and guide referral to a gynecologic oncologist. Neither imaging results (Table 2) nor CA-125 levels alone are sufficiently accurate to diagnose ovarian cancer.  CA-125 is elevated in 90% of women with advanced ovarian cancer but only in 50% of those diagnosed with stage I disease. In addition, CA-125 elevation is associated with many other benign conditions, including pregnancy, leiomyomas, liver or kidney disease, pelvic inflammatory disease, endometriosis, and benign ovarian tumors.

Because of the observed rapid doubling time for ovarian cancer, if imaging cannot quickly characterize an ovarian lesion as benign, or if clinical indicators (e.g. CA-125 levels) or patient risk factors, (e.g. family history or genetic markers) suggest cancer, current recommendations are that the lesion should be resected rather than followed.  Because all these indicators even in combination are nonspecific, surgical removal is >3 times more likely to yield a benign mass than a cancer.


Table 2. Diagnosis of Ovarian Malignancy with Imaging for Asymptomatic Adnexal Masses
Modality
Sensitivity
Specificity
Trans Vaginal Ultrasound (TVUS) 92 60
MRI
83†
84†
MRI after indeterminate US* 81 98

Data from McDonald and Modesitt, 2006

*Includes both asymptomatic and symptomatic masses.

† MRI sensitivity and specificity, 96.6 and 83.7, respectively, in study of women with clinically suspected adnexal masses.




Figure 1. An algorithm for incidental adnexal mass evaluation
*If CA-125 elevated, refer to gynecologic oncologist. If CA-125 normal, refer to general gynecologist or gynecologic oncologist based on clinical assessment of risk for ovarian cancer.
†May need evaluation by gynecologist if sympomatic or large size (>5-6 cm) could cause torsion
‡Suspect endometrioma, dermoid, fibroma, exophytic fibroid, or peritoneal inclusion cyst



Ultrasound Characterization of Adnexal Masses
Incidental adnexal masses represent a wide variety of pathologies including functional cysts, sequelae of prior infection, endometriosis, benign or malignant neoplasms, and those originating from adjacent pelvic organs. The goal of imaging is to differentiate between benign and malignant disease. Transvaginal ultrasound (TVUS) is the preferred method for initial evaluation. It is usually combined with transabdominal ultrasound, which may be necessary to detect both ovaries and can detect ancillary features of malignancy such as hydronephrosis, ascites, and pleural effusions.

Ultrasound features of a benign mass (Figure 2) are a simple unilocular cyst with a thin smooth wall. Complex cysts with hyperechoic regions may indicate a dermoid, and cysts with uniform hypoechoic texture can suggest endometriomas.  These are benign lesions, which when suspected on ultrasound, are often referred for definitive characterization with MRI (Figure 2). Because ultrasound features suggesting a benign lesion are well understood, the reported negative predictive value of ultrasound for malignancy is high at 98%.

Features suggestive of malignancy include that of a complex cyst (Figure 3) with thickened walls, septations, papillary solid components and flow detected on Doppler. However, because many physiologic cysts and benign tumors have similar characteristics to malignancy, specificity of ultrasound for ovarian cancer is low (Table 2).

 
Figure 2. Benigh Cyst - Transvaginal ultrasound image of the right adnexal in this postmenopausal patient reveals a 2.0 cm simple unilocular cyst. This completely resolved on follow-up imaging in 3 months.
 
Figure 2. Benign Cyst - Transvaginal ultrasound image of the right adnexa in this postmenopausal patient reveals a 2.0 cm simple unilocular cyst. This completely resolved on follow-up imaging in 3 months.








Figure 3. Ovarian Cancer - Transvaginal ultrasound image of the pelvis (A) demonstrates a large complex cystic mass (arrows).  Transabdominal ultrasound image of the upper abdomen (B) demonstrates ascites (arrows) around the liver.
Figure 3. Ovarian Cancer - Transvaginal ultrasound image of the pelvis (A) demonstrates a large complex cystic mass (arrows).  Transabdominal ultrasound image of the upper abdomen (B) demonstrates ascites (arrow) around the liver.


MRI Characterization of Adnexal Masses
MRI reduces the number of surgeries on benign adnexal lesions by definitively characterizing them in selected cases. Adnexal lesions with ultrasound features suggesting an endometrioma, dermoid, or an extra-ovarian lesion (e.g. hydrosalpinx, peritoneal inclusion cyst, peritubal cyst), or those appearing homogeneously solid (ovarian fibroma or exophytic uterine or broad ligament fibroid) are further characterized by MRI. However, MRI is usually not helpful for characterizing many complex cystic intra-ovarian masses.  When ovarian lesions that are indeterminate on ultrasound are then examined with contrast enhanced MRI, the sensitivity and specificity of the combined examinations for ovarian cancer are 81% and 98%.

Scheduling
Ultrasound can be performed at all MGH imaging facilities and MRI can be performed at Mass General Imaging in Waltham, Mass General Imaging Chelsea, or the main MGH campus. These studies can be ordered online via the Radiology Order Entry (http://mghroe ) or by calling 4-XRAY (617-724-9729).

  Further Information
For further questions on imaging of adnexal masses, please contact , Staff Radiologist in the Abdominal Imaging and Intervention Division at 617-726-8396.

We would like to thank Neil S. Horowitz, M.D., Gynecological Oncologist, for his advice and assistance in the preparation of this article.












This article provided useful information about the appropriate use of imaging studies:



Note: clicking one of these options will close this window.









References
   

ACOG Committee on Gynecologic Practice. (2002) The role of the generalist obstetrician-gynecologist in the early detection of ovarian cancer. Gynecol Oncol 87: 237-9

Fishman, DA, Cohen, L, Blank, SV, Shulman, L, Singh, D, Bozorgi, K, Tamura, R, Timor-Tritsch, I and Schwartz, PE. (2005) The role of ultrasound evaluation in the detection of early-stage epithelial ovarian cancer. Am J Obstet Gynecol 192: 1214-21

Kinkel, K, Lu, Y, Mehdizade, A, Pelte, MF and Hricak, H. (2005) Indeterminate ovarian mass at US: incremental value of second imaging test for characterization--meta-analysis and Bayesian analysis. Radiology 236: 85-94

McDonald, JM and Modesitt, SC. (2006) The incidental postmenopausal adnexal mass. Clin Obstet Gynecol 49: 506-16

Sohaib, SA, Mills, TD, Sahdev, A, Webb, JA, Vantrappen, PO, Jacobs, IJ and Reznek, RH. (2005) The role of magnetic resonance imaging and ultrasound in patients with adnexal masses. Clin Radiol 60: 340-8

Yamashita, Y, Torashima, M, Hatanaka, Y, Harada, M, Higashida, Y, Takahashi, M, Mizutani, H, Tashiro, H, Iwamasa, J and Miyazaki, K. (1995) Adnexal masses: accuracy of characterization with transvaginal US and precontrast and postcontrast MR imaging. Radiology 194: 557-565